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The research interests of the lab revolve around dissecting the mechanisms by which neuronal dysfunction and degeneration occurs in neurodegenerative diseases, especially in Tauopathies such as Alzheimer’s disease.
The over-arching aim is to use this knowledge both for identification of disease-modifying drug targets and for generation of novel, “patient-specific” diagnostic tools that may enable earlier diagnosis and improved disease stratification.
To achieve this, a number of experimental paradigms are employed to model aspects of tauopathy in vitro and in vivo, and a range of biochemical and biophysical methodologies are utilized to study the ensuing pathological processes.
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